Seng H Cheng Selected Research

Glycosphingolipids

1/2022	Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease.
1/2017	Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease.
1/2016	Molecular basis for globotriaosylceramide regulation and enzyme uptake in immortalized aortic endothelial cells from Fabry mice.
6/2015	Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis.
4/2015	Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.
1/2011	Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.
11/2010	Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.
7/2010	Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
7/2009	Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
5/2007	Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.

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Seng H Cheng Research Topics

Disease

13	Gaucher Disease (Gaucher's Disease) 01/2021 - 08/2002
9	Fabry Disease (Fabry's Disease) 01/2018 - 06/2002
8	Cystic Fibrosis (Mucoviscidosis) 09/2015 - 02/2006
8	Infections 01/2014 - 02/2002
8	Hypoxia (Hypoxemia) 09/2010 - 02/2002
7	Parkinson Disease (Parkinson's Disease) 01/2017 - 06/2011
7	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2015 - 04/2006
7	Glycogen Storage Disease Type II (Pompe's Disease) 10/2014 - 11/2004
6	Dementia (Dementias) 01/2022 - 06/2011
6	Synucleinopathies 01/2017 - 07/2011
5	Disease Progression 01/2017 - 06/2008
4	Sandhoff Disease (Sandhoff's Disease) 01/2019 - 07/2006
4	Huntington Disease (Huntington's Disease) 01/2016 - 06/2012
4	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 06/2015 - 03/2011
4	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2014 - 04/2008
3	Neuroinflammatory Diseases 01/2022 - 09/2012
3	Inflammation (Inflammations) 01/2017 - 07/2006
3	Neuromuscular Diseases (Neuromuscular Disease) 06/2015 - 05/2011
3	Neoplasms (Cancer) 03/2011 - 10/2004
3	Insulin Resistance 06/2010 - 05/2007
3	Niemann-Pick Diseases (Niemann Pick Disease) 05/2009 - 09/2005
3	Heart Failure 08/2008 - 07/2003
3	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 04/2008 - 02/2006
3	Hyperplasia 04/2005 - 03/2004
2	Cognitive Dysfunction 01/2022 - 02/2013
2	Nervous System Diseases (Neurological Disorders) 01/2022 - 09/2012
2	Muscular Dystrophies (Muscular Dystrophy) 01/2020 - 09/2010
2	Brain Diseases (Brain Disorder) 01/2019 - 01/2016
2	Type A Niemann-Pick Disease 01/2019 - 10/2012
2	Phenylketonurias (Phenylketonuria) 01/2018 - 01/2017
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 07/2002
2	Memory Disorders (Memory Loss) 01/2017 - 07/2011
2	Gliosis 01/2016 - 10/2007
2	Marfan Syndrome (Marfan's Syndrome) 01/2016 - 04/2015
2	Paralysis (Palsy) 06/2015 - 12/2011
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 06/2015 - 12/2011
2	Cardiomyopathies (Cardiomyopathy) 10/2014 - 07/2003
2	Myotonic Dystrophy (Dystrophia Myotonica) 04/2013 - 08/2012
2	Glycogen Storage Disease (Glycogenosis) 01/2013 - 08/2010
2	GM2 Gangliosidoses (GM2 Gangliosidosis) 08/2012 - 11/2011
2	Body Weight (Weight, Body) 01/2011 - 07/2009
2	Inborn Genetic Diseases (Disease, Hereditary) 12/2010 - 04/2006
2	Acute Intermittent Porphyria (Porphyria, Acute) 01/2010 - 09/2007
2	Ischemia 05/2009 - 02/2005
2	Peripheral Nervous System Diseases (PNS Diseases) 03/2007 - 03/2007

Drug/Important Bio-Agent (IBA)

18	EnzymesIBA 01/2021 - 08/2002
15	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2002
14	GlycosphingolipidsIBA 01/2022 - 06/2002
12	Glucosylceramidase (Glucocerebrosidase)IBA 01/2017 - 08/2002
11	LipidsIBA 01/2021 - 01/2004
11	AcidsIBA 10/2014 - 08/2005
9	ceramide glucosyltransferaseIBA 01/2022 - 07/2007
9	Messenger RNA (mRNA)IBA 01/2014 - 03/2002
7	SynucleinsIBA 01/2017 - 06/2011
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 03/2002
7	globotriaosylceramide (globotriosylceramide)IBA 01/2017 - 06/2002
7	GlycogenIBA 10/2014 - 11/2004
6	GalactosidasesIBA 01/2018 - 11/2010
6	Etoposide (VP 16)FDA LinkGeneric 05/2009 - 02/2002
5	Pharmaceutical PreparationsIBA 01/2019 - 04/2009
5	Antisense OligonucleotidesIBA 10/2014 - 07/2010
5	Glucose (Dextrose)FDA LinkGeneric 06/2010 - 07/2002
4	HydrolasesIBA 04/2016 - 06/2002
4	GlycolipidsIBA 01/2016 - 01/2004
4	Glucosylceramides (Glucocerebrosides)IBA 06/2015 - 08/2002
4	GlucosidasesIBA 10/2014 - 06/2011
4	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 10/2012 - 09/2005
4	alpha-Glucosidases (Acid Maltase)IBA 08/2010 - 08/2005
3	Mannose (D-Mannose)IBA 04/2016 - 02/2004
3	human GAA protein (Myozyme)FDA Link 10/2014 - 11/2004
3	Insulin (Novolin)FDA Link 08/2014 - 06/2008
3	eliglustatIBA 11/2010 - 07/2007
3	Deferoxamine (Desferal)FDA LinkGeneric 09/2010 - 07/2002
3	Tripeptidyl-Peptidase 1IBA 04/2008 - 02/2006
3	alpha-Galactosidase (Beano)IBA 02/2004 - 06/2002
2	GangliosidesIBA 01/2022 - 05/2007
2	neodymium pyrocatechin disulfonate (NPD)IBA 01/2019 - 05/2007
2	Glycoproteins (Glycoprotein)IBA 01/2019 - 04/2016
2	G(M2) Ganglioside (Ganglioside GM2)IBA 01/2019 - 07/2006
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 02/2005
2	UbiquitinIBA 01/2017 - 07/2011
2	DNA (Deoxyribonucleic Acid)IBA 09/2015 - 12/2007
2	polyglutamineIBA 05/2014 - 06/2012
2	miglustat (Zavesca)FDA Link 01/2014 - 06/2010
2	Lysergic Acid Diethylamide (LSD)IBA 10/2012 - 04/2006
2	Hexosaminidases (Hexosaminidase)IBA 11/2011 - 07/2006
2	imiglucerase FDA Link 06/2010 - 02/2004
2	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 01/2010 - 09/2007
2	SphingomyelinsIBA 05/2009 - 09/2005
2	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2009 - 07/2003
2	PPAR alphaIBA 12/2007 - 07/2002
2	Hypoxia-Inducible Factor 1IBA 12/2007 - 03/2002
2	LigandsIBA 08/2005 - 11/2004
2	Phenobarbital (Luminal)FDA Link 04/2005 - 10/2004
2	beta-Adrenergic Receptor KinasesIBA 04/2005 - 10/2004

Therapy/Procedure

15	Therapeutics 01/2021 - 07/2003
10	Enzyme Replacement Therapy 01/2018 - 02/2004
4	Enzyme Therapy 10/2014 - 07/2007
2	Intravenous Administration 08/2014 - 06/2010
2	Injections 10/2012 - 10/2007